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Comments(52)

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   comment scienceprofessionalhub.co.ke says

   May 17, 2025 at 7:11 pm

   Weitere Indikationen sind eine zunehmende Milzvergrößerung oder ein aderlassrefraktärer
   wasserinduzierter Juckreiz. Bei einigen Patienten führt der durch regelmäßigen Aderlass erzeugte
   Eisenmangel zu Müdigkeit oder Konzentrationsschwäche, sodass diese eine Umstellung von einer eisendepletierenden auf
   eine zytoreduktive Therapie wünschen. Der Aderlass, eine seit Hippokrates praktizierte
   Methode, ist die Therapie der ersten Wahl.
   Der Flüssigkeitsverlust kann durch orale oder gegebenenfalls auch intravenöse Zufuhr
   ausgeglichen werden. Durch den Aderlass kann die Blutviskosität erfolgreich gesenkt werden, allerdings kann die Thrombozytenzahl durch Überkompensation vorübergehend leicht ansteigen (18).

   Ob eine Substitution mit Testosteron zu einer verringerten Mortalität bei KHK-Patienten führt, muss jedoch erst noch in weiteren Studien überprüft
   werden. Thrombozyten können bei PV-Patienten ebenfalls an der Entstehung von Thrombosen beteiligt sein. Nach den Ergebnissen der ECLAP-Studie (19)
   – einer randomisierten, placebokontrollierten Doppelblindstudie mit 518
   Patienten – haben Patienten, die täglich 50 bis one hundred mg Acetylsalicylsäure
   (ASS) einnehmen ein geringeres Thromboserisiko. Kritiker der Studie wenden ein,
   dass einzelne Patienten dieser Studie nur deshalb eine ASS-Therapie benötigten, weil ihr Hämatokrit
   nur unzureichend abgesenkt war (20). Da einzelne PV-Patienten ein erhöhtes
   Blutungsrisiko haben, ist beim Einsatz von ASS auf etwaige Blutungskomplikationen zu achten.
   Unser vorgeschlagener Diagnosealgorithmus für JAK2-unmutierte Polyzythämie bei
   Erwachsenen ist in Abbildung 1 dargestellt. Zusammenfassend kann
   gesagt werden, dass die Poly­zythämie und Erythrozytose wichtige
   Laborbefunde sind, welche eine weitere Abklärung triggern sollten. Parameter, die für die Kategorisierung dieser Art von Polyzythämie wegweisend sind, umfassen den Epo-Spiegel im Serum und den P50-Wert.

   Um eine im Vergleich flachere Testosteron-Wirkungskurve zu erreichen, stellten die
   Baseler Internisten auf das intramuskulär zu applizierende
   und länger wirksame Präparat Testosteronundecanoat um.
   In Zukunft soll sich der Zeitpunkt der Testosteron-Substitution am klinischen Allgemeinzustand
   des Patienten sowie am peripheren Androgenspiegel
   orientieren. Zu beachten ist außerdem das erhöhte Prostatakarzinom-Risiko unter der Substitutionstherapie, dem Affected Person wurde empfohlen,
   sich regelmäßig klinisch und sonografisch untersuchen lassen. Inzwischen lagen die Ergebnisse
   der Knochenmarkspunktion vor, wonach ein normo- bis leicht
   hyperzelluläres Knochenmark mit leichter Hyperplasie der Erythropoese bestand.
   Es fanden sich kein morphologischer Anhalt für eine myeloproliferative Erkrankung und keine genetischen Aberrationen. “Die initial geschilderte abdominale Symptomatik interpretierten wir im Rahmen der nehmen bodybuilder frauen testosteron (scienceprofessionalhub.co.ke)überdosierung bei Regredienz im Verlauf
   als potenzielle Nebenwirkung”, so Kofler und Mitarbeiter.
   Der Prozess der Andropause und ihre hormonellen Veränderungen verläuft langsamer – quasi schleichend – und wird daher häufig nicht erkannt. Bei unbehandeltem Prostatakrebs sollte auf eine Testosteron­substitution verzichtet werden. Auch bei den extrem seltenen Fällen von männlichem Brustkrebs sollte keine Testosteron­behandlung erfolgen. Neben Erythropoetin ist auch Cortisol ein Erythropoese-stimulierendes Hormon. Erhöhte Cortisolspiegel als Ausdruck eines Cushing-Syndroms oder eines Morbus Cushing können somit ebenfalls eine Polyglobulie verursachen.
   Männer mit einer niedrigen Testosteron­konzentration sterben häufiger an Tumor- oder Herz-Kreislauf-Erkrankungen als Männer mit einer physiologischen Konzentration dieses Sexual­hormons. So ist ein niedriger Testosteron­spiegel häufig mit einem erhöhten allgemeinen Krankheits­risiko assoziiert. Dies wurde in einer Studie mit 930 Männern mit koronarer Herz­krankheit (KHK) bestätigt. Über einen Zeitraum von sieben Jahren wurden alle Todesfälle erfasst und mit dem Testosteron­wert korreliert. In der Gruppe mit Hormon­defizit struggle die Mortalitäts­rate fast doppelt so hoch wie in der Gruppe mit normalen Testosteron­spiegeln.
   Durch eine homozygote Mutation des VHL-Gens entsteht ein VHL-Protein mit reduzierter Aktivität, sodass die a-Ketten auch bei Normoxämie nicht abgebaut werden. Die dadurch hervorgerufene Erhöhung der Erythropoietin-Ausschüttung führt zu einem deutlichen Anstieg des Hämoglobinwertes. Dies weist auf andere Ursachen, wie zum Beispiel die beobachtete vermehrte Produktion des vaskulären endothelialen Wachstumsfaktors (VEGF), die ebenfalls durch HIF reguliert wird, hin (3). Angeborene Erythropoietin(EPO)-Rezeptor-Mutationen führen zu einer Verkürzung des intrazellulären Anteils des Rezeptorproteins (2). Dadurch können unfavorable Regulatoren nicht mehr binden, sodass es zu einer konstitutiven Aktivierung des Rezeptors kommt. Im Gegensatz zur PV haben die Betroffenen kein erhöhtes Risiko für Thrombosen und Blutungen, was dafür spricht, dass die Erythrozytose nicht alleine dafür verantwortlich ist. Während die Menopause mit dem Aus­bleiben der Regelblutung offensichtlich wird, fehlt ein solches Kardinalereignis beim Mann.
   Im Hoden spielt Testosteron eine wesentliche Rolle bei der Spermatogenese. Über diese androgene Wirkung hinaus werden Sexualverhalten und -aktivität beim Mann beeinflusst. Dementsprechend vielgestaltig ist die klinische Ausprägung eines Testosteronmangels. Die Substitutionsbehandlung mit Testosteronpräparaten ist in der Praxis fest etabliert. Therapienutzen und Risiken müssen jedoch je nach Indikation sorgfältig abgewogen werden.
   Der Blutdruck sank in den Normbereich, ebenso sanken der Hämatokrit und das Hämoglobin. Hier wird gewichtsadaptiert ein Aderlass durchgeführt und mit isotonischer Kochsalzlösung substituiert. Bei einer absoluten Polyglobulie erfolgt die weitere diagnostische Abklärung der Grunderkrankung. Dazu zählen unter anderem die Kardiodiagnostik mittels Echokardiographie, der Röntgenthorax, die Sonographie und ggf. Durch hohe Flüssigkeitsverluste nach lang andauerndem Erbrechen oder massiven Diarrhoen ändert sich das Zell-Plasma-Verhältnis.

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   May 19, 2025 at 2:45 am

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   Alternatively, pure supplements and life-style modifications could additionally be recommended
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   In addition to its function in sexual development, testosterone
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   Throughout the transition, a transgender male goes
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   Proponents of early surgery point to adult patients
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   The Girth-reduction clitoroplasty permits reduction of the clitoris without dissection of the neurovascular bundles extending between the 9 and
   three o’clock positions. They feel that this tissue is
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   The surge in testosterone throughout puberty contributes to the
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   The size of the clitoris may continue to increase throughout adolescence and attain its maximum size in early maturity.
   One potential impact of testosterone use in females is an increase in clitoral
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   When testosterone ranges improve, these tissues can become engorged and lead to a temporary improve in clitoral measurement.

   Whereas taking testosterone gender-affirming hormone remedy, you might expertise bodily, medical, and psychological adjustments, which can be momentary
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   Ultimately, the success of this operation will depend
   upon long-term follow-up and the demonstration of intact sensation and
   sexual operate. Glans reduction is performed by superficial excision of the epithelium of the glanular
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   Also, watch out about giving dietary supplements to a baby, until really helpful by their healthcare
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   For over eighty years, women have been using testosterone to treat signs of perimenopause or
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   The specific kind of surgical process will rely
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   In some instances, surgical interventions may be necessary to handle an enlarged clitoris,
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   Looking For support from healthcare professionals and trusted sources, such
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   Being, can help make positive that people receive the care and help they
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   It’s necessary to speak together with your doctor if you’re concerned about the measurement of your clitoris and any other symptoms you might be experiencing.
   This is commonly seen in infants who are born withcongenital adrenal hyperplasia (CAH), as properly.
   This genetic dysfunction can cause an toddler to produce an extreme quantity of
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   Pre-meta is distinguished from a full metoidioplasty because the scrotum isn’t constructed and
   the urethra just isn’t lengthened.Pre-meta
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   similar to metoidioplasty. Patients could later select to
   complete the metoidioplasty at a later date by choosing a
   scrotoplasty with expanders or implants. We assessed cross-sectional associations
   between current testosterone use and sexual function.
   For participants who completed a couple of annual questionnaire, we restricted our evaluation to solely
   include their first year of responses.

4. 

   comment Max says

   May 19, 2025 at 12:25 pm

   Le dosage du bodybuilder masculin de ce stéroïde serait généralement de 500 à 1250 mg par semaine et la durée du cycle serait de 8 à 20
   semaines, en fonction bien sûr des objectifs de l’athlète.
   La Testostérone Cypionate est une model synthétique de l’hormone Testostérone naturellement produite.
   Cette hormone est responsable de nombreuses caractéristiques physiques et psychiques
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   Es caractéristiques seront les mêmes que la Testostérone soit produite naturellement ou par l’utilisation de la Testostérone Cypionate.

   La Cypionate peut également augmenter les niveaux d’une autre hormone anabolique dans
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   Cela fait de la testostérone le “père” de tous les
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   Il convient de noter que tous les composés de testostérone, y compris la testostérone Cypionate,
   portent ce ratio d’effets Anabolisant / Androgène noté à 100, car
   ce sont tout simplement de la testostérone.

   La Testostérone Cypionate est une hormone fortement
   anabolique et androgène qui en fait un puissant stéroïde à utiliser si l’on est à la
   recherche de plus de volume et de force musculaire.
   Les androgènes comme la testostérone peuvent protéger vos muscle tissue durement acquis du catabolisme naturel, ouatrophie
   musculaire provoquée par les hormones glucocorticoïdes, et inhiber les effets indésirables liés.
   En outre, la Testostérone Cypionate a la capacité
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   ce qui vous permettra d’améliorer l’endurance en augmentant l’oxygénation du sang.

   Plus de globules rouges peut aussi améliorer la récupération après une activité
   physique intense.
   Si vous n’en avez pas encore discuté avec votre médecin, ou
   si vous avez des doutes sur les raisons pour
   lesquelles vous prenez ce médicament, consultez-le.

   Ne cessez pas de prendre ce médicament sans avoir consulté votre médecin au préalable.
   Le Cypionate de Testostérone Injectable
   250mg/ml est administré par voie intramusculaire. Il est recommandé de consulter un professionnel de la santé pour l’administration appropriée de
   ce médicament. La posologie et la fréquence d’administration dépendent des besoins
   individuels du patient et doivent être déterminées
   par un médecin. Il n’a pas été confirmé que le cypionate de testostérone est sûr
   et efficace pour les enfants de moins de 12 ans. En 1937, la première
   testostérone contrôlée par ester allait arriver
   sur le marché grâce à Schering et à leur nouveau produit de propionate de testostérone.

   Assurez-vous d’informer votre médecin de tous les médicaments, vitamines ou herbes que vous prenez.
   Pour savoir remark ce médicament pourrait interagir avec quelque selected d’autre
   que vous prenez, parlez-en à votre médecin ou à votre pharmacien.
   Ne jetez pas de médicaments dans les eaux usées (par ex.
   pas dans l’évier ni dans la cuvette des cabinets) ni avec les ordures ménagères.
   Demandez à votre pharmacien remark vous débarrasser
   des médicaments inutilisés ou périmés. Ce médicament est disponible sous divers
   noms de marque ou sous différentes présentations, ou les deux.
   Une marque spécifique de ce médicament n’est peut-être pas offerte sous toutes les formes
   ni avoir été approuvée contre toutes les affections dont il est query ici.

   Ce médicament pourrait nuire aux personnes pour lesquelles il n’a pas
   été prescrit.
   L’interférence d’un médicament avec un autre n’entraîne pas toujours l’interruption de la
   prise de l’un d’eux. Demandez à votre médecin quelle est la conduite à tenir
   en cas d’interactions médicamenteuses. Ne donnez pas ce médicament
   à quiconque, même à quelqu’un qui souffre des mêmes symptômes que les vôtres.

   Le cypionate de testostérone est administré par injection dans votre muscle (habituellement les fesses).
   Votre professionnel de la santé vous apprendra remark injecter le
   médicament profondément dans votre muscle. Un faible
   taux de testostérone chez les hommes peut entraîner des changements d’humeur, une mauvaise concentration, une dysfonction érectile (difficulté
   à obtenir ou à maintenir une érection)
   et une faible libido. Elle peut également causer une réduction de d’où vient la testostérone chez les
   fille (Max)
   croissance du pénis et des testicules, une gynécomastie (croissance
   des seins), la perte des poils et de la masse musculaire,
   l’anémie et l’ostéoporose.
   Les médicaments génériques coûtent habituellement moins cher que la model de marque.
   Dans certains cas, ils peuvent ne pas être disponibles dans toutes les concentrations ou formes sous
   forme de médicament d’origine. Il favorise également
   la synthèse du glycogène, fournissant plus de carburant pour les entraînements intenses, augmentant ainsi l’endurance et la drive.
   La testostérone cypionate (testostérone à libération retardée) est un produit
   pour un cycle de prise de masse. Il est nécessaire d’ajouter un anti-œstrogène à votre
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   la manufacturing de testostérone. La testostérone étant le principal androgène masculin, on peut s’attendre
   à des effets secondaires androgènes prononcés tels qu’une augmentation de
   la sécrétion sébacée, de l’acné, de la pilosité
   du corps et du visage, ainsi qu’une calvitie masculine.

   Le cypionate de testostérone est utilisé pour traiter les
   symptômes d’hypogonadisme chez les hommes. Dans cet état,
   les hommes ne produisent pas assez de testostérone, l’hormone sexuelle.
   Le cypionate de testostérone ne devrait s’utiliser que si la déficience en testostérone a été confirmée par les symptômes
   et les analyses de sang. La testostérone est facilement l’hormone
   la plus efficace qui peut être utilisée pour la musculation. Il
   augmente la masse musculaire, et joue également un rôle majeur
   dans nos décisions et sans libido. La testostérone peut être définie comme la conquête, le désir, la sexualité,
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   term for mixing multiple forms of AAS. Some athletes
   also include different synthetic hormones, similar to development hormone and insulin.
   The dosing of AAS in energy sports activities tends to
   be extra liberal, as many federations don’t check for these and different substances.

   While more potent effects could additionally be
   seen at greater doses, the chance of unwanted side effects increases as
   properly. They have been proven to increase muscle mass, which results in elevated
   pace and energy output (5).
   It was demonstrated that AASs enhance the chance of premature death, especially amongst topics with other
   pathologies and/or psychiatric illnesses [36].
   A survey carried out in 21 gyms in Britain reported that 8% of
   respondents declared having taken AASs in their life.
   One Other study within the UK showed that 70% of the clientele in a health and fitness community were AAS customers [37].
   A 2011 survey of Ontario college students in grades 7 to 12 reported that
   1.2 per cent had used anabolic steroids no much less than once.
   A 2004 survey of Canadians (aged 15+) reported that 0.6 per cent had used anabolic
   steroids no much less than once. ​Anabolic steroids have the identical chemical construction as steroids present in testosterone.
   The muscle-building effects of the medication make them interesting
   to athletes.
   While steroids may be effective for managing
   certain medical conditions, they might have dangerous unwanted
   effects, especially with long-term use. These can embrace
   weight gain, weakened bones, high blood pressure, hormonal imbalances, elevated threat of heart disease, liver damage, and psychological results such as aggression and temper swings.
   It Is essential to attenuate risks by using the bottom effective dose for the shortest duration needed and underneath correct
   medical supervision. Of nice interest is the relevance of 11β-HSD1 to human inflammatory disease.

   In superior most cancers, glucocorticoids usually work by lowering the oedema surrounding tumours (Khadka et al, 2023).

   Dexamethasone is highly anti-inflammatory and notably helpful when fluid retention is unwelcome – corresponding to in instances of cerebral oedema (NICE, 2025a).
   Corticosteroids could additionally be simpler than non-steroidal anti-inflammatory medicine (NSAIDs), however long-term steroid use could cause extra opposed effects compared with NSAIDs (Twycross
   et al, 2021). Oral corticosteroids may be given for short or lengthy intervals of time,
   depending on the scenario. Facet results that may happen with short-term use
   are usually less severe than those who occur with long-term use.

   Muscle dysmorphia, characterized by an excessive and pathological preoccupation with muscularity, is prevalent among AAS users.
   It has been reported that muscle dysmorphia impacts roughly 1.5% to
   6% of Swedish fitness center guests, as indicated by a scholar thesis [35].
   AAS users might develop this condition due to an obsession with the
   idea that their muscularity just isn’t enough. Pope et al.

   [36] advised that the significant hole between men’s actual muscularity and their body ideals could
   contribute to the rise in issues like muscle dysmorphia and anabolic steroid abuse.

   Steroid use cannot be stopped abruptly; tapering the drug provides the adrenal glands time to return to their normal patterns of secretion. Withdrawal
   signs and indicators (weakness, fatigue, decreased appetite, weight reduction, nausea, vomiting, diarrhea, belly pain) can mimic many other medical problems.
   In the case of topical testosterone therapy, the serum testosterone degree ought to be measured two to eight hours after utility.
   This measurement is often done after fourteen days of starting the remedy or throughout dose titration to
   evaluate the effectiveness of the therapy. Moreover, AAS abuse can stimulate the sebaceous glands, resulting in elevated production of sebum (oily
   substance) in the skin. This can contribute to the development of extreme zits in AAS users, particularly
   at higher doses. Corticosteroids cut back the speed of protein synthesis in skeletal
   muscle, and actually favour protein catabolism and the technology of
   glucose from amino acids liberated by this course of.

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